Suzuki Y, Ishihara R, Ishii Y, Nakazawa A, Deguchi K, Matsumoto Y, Nishinari C, Nakane Y, Fukumoto T
Section of Studies, Tokyo Clinical Research Center.
Jpn J Antibiot. 1996 Oct;49(10):947-65.
In order to evaluate antimicrobial activity of cefodizime (CDZM), minimum inhibitory concentrations (MICs) of CDZM and control drugs were determined against clinical isolates collected from nation-wide medical institutions and in our laboratory from September to December of 1992 and from September to December of 1995. The results are summarized as follows: 1. Bacterial species with no or few strains resistant to CDZM included Streptococcus pyogenes, Haemophilus influenzae, Citrobacter koseri, Proteus mirabilis and Neisseria gonorrhoeae. The range of MIC values of CDZM against Klebsiella pneumoniae was spread. Other strains, Streptococcus pneumoniae, Moraxella subgenus Branhamella catarrhalis, Escherichia coli, Citrobacter freundii, Enterobacter spp., Serratia marcescens, Proteus vulgaris, Morganella morganii, Providencia spp., Peptostreptococcus spp. and Bacteroides fragilis group were resistant to cephems including CDZM. 2. The MIC90's of CDZM were 0.05 approximately 3.13 micrograms/ml against Streptococcus spp., H. influenzae, M. (B.) catarrhalis, E. coli, Klebsiella spp., P. mirabilis, N. gonorrhoeae and Peptostreptococcus spp. obtained in 1995 that were frequently found in daily treatment of infections. It appears that the effectiveness of CDZM was still relatively high against community-acquired infections. 3. Among H. influenzae isolates included imipenem (IPM)-resistant and norfloxacin (NFLX)-resistant strains. The MIC-range of CDZM against strains collected in 1995 including IPM-resistant and NFLX-resistant strains was < or = 0.025 approximately 0.1 microgram/ml, and MIC90 against these strains was 0.05 microgram/ml. CDZM showed strong antimicrobial activities against H. influenzae strains resistant to carbapenems and new-quinolones.
为评估头孢地嗪（CDZM）的抗菌活性，于1992年9月至12月以及1995年9月至12月期间，针对从全国医疗机构及本实验室收集的临床分离株，测定了CDZM及对照药物的最低抑菌浓度（MIC）。结果总结如下：1. 对CDZM耐药菌株极少或无耐药菌株的细菌种类包括化脓性链球菌、流感嗜血杆菌、科氏柠檬酸杆菌、奇异变形杆菌和淋病奈瑟菌。CDZM对肺炎克雷伯菌的MIC值范围较宽。其他菌株，如肺炎链球菌、卡他莫拉菌（莫拉克斯菌属布兰汉菌亚属）、大肠埃希菌、弗氏柠檬酸杆菌、肠杆菌属、粘质沙雷菌、普通变形杆菌、摩根摩根菌、普罗威登斯菌属、消化链球菌属和脆弱拟杆菌群对包括CDZM在内的头孢菌素耐药。2. 1995年获得的CDZM对链球菌属、流感嗜血杆菌、卡他莫拉菌、大肠埃希菌、克雷伯菌属、奇异变形杆菌、淋病奈瑟菌和消化链球菌属的MIC90为0.05至约3.13微克/毫升，这些菌株在日常感染治疗中较为常见。看来CDZM对社区获得性感染的有效性仍然相对较高。3. 在流感嗜血杆菌分离株中包括对亚胺培南（IPM）耐药和对诺氟沙星（NFLX）耐药的菌株。1995年收集的包括对IPM耐药和对NFLX耐药菌株在内的CDZM对这些菌株的MIC范围为≤0.
