Igari J
Department of Clinical Pathology, School of Health Sciences, Faculty of Medicine, University of the Ryukyus.
Jpn J Antibiot. 1990 Oct;43(10):1723-82.
We investigated susceptibilities of clinical bacterial isolates to imipenem (IPM) and other antimicrobial agents at 459 hospital laboratories throughout Japan from September to December of 1988. In this study, identification and susceptibility testing were performed at each hospital laboratory and the tests were carried out according to the 1-dilution or 3-dilution disc technique in which susceptibilities are classified into 4 grades: , ++, + and -. IPM had significantly high activity against Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter aerogenes, Enterobacter cloacae, Salmonella spp., Citrobacter freundii, Proteus mirabilis, Providencia rettgeri, Acinetobacter calcoaceticus, Moraxella catarrhalis, Alcaligenes spp., Peptococcus spp./Peptostreptococcus spp., Bacteroides fragilis and Bacteroides spp. and should slightly lower activities on coagulase-negative staphylococci (CNS), Enterococcus faecalis, Haemophilus influenzae, Serratia marcescens, Proteus vulgaris, Providencia stuartii and Pseudomonas aeruginosa than on the above mentioned bacteria. In a comparative study on activities of IPM against bacteria from different clinical sources, no remarkable differences were found due to different sources among S. pneumoniae, E. faecalis, H. influenzae, E. coli, K. pneumoniae, E. cloacae, C. freundii, P. mirabilis or A. calcoaceticus, whereas slight differences were found among Staphylococcus aureus, CNS, S. marcescens and P. aeruginosa.
1988年9月至12月期间，我们在日本全国459家医院实验室调查了临床分离细菌对亚胺培南（IPM）及其他抗菌药物的敏感性。在本研究中，各医院实验室进行了细菌鉴定和药敏试验，试验采用1倍稀释或3倍稀释纸片法，药敏结果分为4级： 、++、+和 - 。IPM对肺炎链球菌、化脓性链球菌、无乳链球菌、淋病奈瑟菌、大肠埃希菌、肺炎克雷伯菌、产酸克雷伯菌、产气肠杆菌、阴沟肠杆菌、沙门菌属、弗劳地枸橼酸菌、奇异变形杆菌、雷氏普罗威登斯菌、醋酸钙不动杆菌、卡他莫拉菌、嗜碱杆菌属、消化球菌属/消化链球菌属、脆弱拟杆菌及其他拟杆菌属具有显著的高活性，而对凝固酶阴性葡萄球菌（CNS）、粪肠球菌、流感嗜血杆菌、黏质沙雷菌、普通变形杆菌、斯氏普罗威登斯菌和铜绿假单胞菌的活性略低于上述细菌。在一项关于IPM对不同临床来源细菌活性的比较研究中，肺炎链球菌、粪肠球菌、流感嗜血杆菌、大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌、弗劳地枸橼酸菌、奇异变形杆菌或醋酸钙不动杆菌因来源不同未发现显著差异，而金黄色葡萄球菌、CNS、黏质沙雷菌和铜绿假单胞菌之间存在细微差异。
