Farrace S, Frontoni S, Gambardella S, Menzinger G, Rossetti L
DASRS, Medicine Department, Pratica di Mare, Pomezia, Rome, Italy.
J Hypertens. 1996 Sep;14(9):1087-92. doi: 10.1097/00004872-199609000-00007.
To evaluate the impact of beta-adrenergic blockade in spontaneously hypertensive rats (SHR) and in their normotensive controls, Wistar-Kyoto (WKY) rats, on whole-body glucose disposal under metabolic steady state conditions, in unrestrained and conscious animals.
SHR (n = 13) and WKY rats (n = 12) underwent a 240 min insulinaemic clamp study with or without a super-infusion (120th to 240th minutes; second step) of propranolol.
From 0 to 120 min (the first step) SHR showed significantly increased glucose uptake, muscle glycogen synthesis and glycogen synthase activity compared with WKY rats. When propranolol was superinfused, glucose uptake and muscle glycogen synthesis in SHR returned to levels similar to those observed in WKY rats during the first step. No significant differences were found for whole-body glycolysis in SHR and WKY in the first and second steps.
Hypertensive rats display an increased insulin sensitivity compared with controls. Beta-Blockade is associated with a reduction in overall glucose metabolism in SHR, but not in WKY rats.
评估β-肾上腺素能阻滞剂对自发性高血压大鼠（SHR）及其正常血压对照Wistar-Kyoto（WKY）大鼠在代谢稳态条件下、无束缚清醒动物全身葡萄糖处置的影响。
SHR（n = 13）和WKY大鼠（n = 12）进行了240分钟的胰岛素钳夹研究，研究过程中有无普萘洛尔的超输注（第120至240分钟；第二步）。
在0至120分钟（第一步）期间，与WKY大鼠相比，SHR的葡萄糖摄取、肌肉糖原合成和糖原合酶活性显著增加。当超输注普萘洛尔时，SHR的葡萄糖摄取和肌肉糖原合成恢复到第一步期间WKY大鼠所观察到的相似水平。在第一步和第二步中，SHR和WKY的全身糖酵解未发现显著差异。
与对照组相比，高血压大鼠表现出更高的胰岛素敏感性。β-受体阻滞剂与SHR整体葡萄糖代谢的降低有关，但与WKY大鼠无关。
