Iellamo F, Legramante J M, Raimondi G, Castrucci F, Massaro M, Peruzzi G
Fisiopatologia Medica, Ospedale S. Eugenio, Dipartimento di Medicina Interna, Università di Roma, Italy.
J Hypertens. 1996 Sep;14(9):1099-104. doi: 10.1097/00004872-199609000-00009.
The aim of the present study was to examine the reproducibility of arterial baroreflex sensitivity (BRS) provided by the spontaneous baroreflex method at rest and during laboratory tests.
Twenty healthy volunteers were studied 24 h apart, in the same laboratory and under the same environmental conditions, at rest, during active standing, while performing mental arithmetics and during static hand-gripping. Systolic blood pressure, mean arterial pressure and pulse interval were continuously and non-invasively measured by using a Finapres device. BRS was evaluated by analysing the slopes of spontaneously occurring sequences of three or more consecutive beats in which systolic blood pressure and pulse interval of the following beat both increased or decreased, in the same direction, in a linear fashion. Individual BRS were obtained by averaging all slopes computed within a given test.
Under each test condition BRS did not differ significantly between the two consecutive days, showing strikingly similar values. The mean group coefficients of variation (CVAR), obtained by averaging individual CVAR, between the two experimental days were 15.0, 13.9 and 19.7% for resting, standing, static hand-gripping and mental arithmetic, respectively. No relationships were found between individual CVAR and individual mean arterial pressure, pulse interval and number of baroreflex sequences under any tested condition, on both experimental days.
These results show that the spontaneous baroreflex method provides good BRS reproducibility under various stimuli that affect the neural control of circulation differently. They also suggest that BRS variability is dependent neither on haemodynamic modifications nor on the degree of baroreflex engagement, but it seems to reflect an inherent feature of the way in which arterial baroreflex modulate the heart period.
本研究旨在检验静息状态及实验室测试期间自发压力反射法所提供的动脉压力反射敏感性（BRS）的可重复性。
20名健康志愿者在同一实验室、相同环境条件下，于静息状态、主动站立时、进行心算时以及静态握力时，间隔24小时接受研究。使用Finapres设备连续无创测量收缩压、平均动脉压和脉搏间期。通过分析三个或更多连续搏动的自发序列斜率来评估BRS，在这些序列中，后续搏动的收缩压和脉搏间期以相同方向呈线性增加或降低。通过对给定测试内计算出的所有斜率求平均值获得个体BRS。
在每种测试条件下，连续两天的BRS无显著差异，显示出极为相似的值。通过对个体变异系数（CVAR）求平均得到的两组平均变异系数，在两个实验日中，静息、站立、静态握力和心算时分别为15.0%、13.9%和19.7%。在两个实验日的任何测试条件下，均未发现个体CVAR与个体平均动脉压、脉搏间期及压力反射序列数量之间存在关联。
这些结果表明，自发压力反射法在不同程度影响循环神经控制的各种刺激下均具有良好的BRS可重复性。它们还表明，BRS变异性既不依赖于血流动力学改变，也不依赖于压力反射参与程度，而是似乎反映了动脉压力反射调节心动周期方式的固有特征。
