Wu M Y, Chen H F, Ho H N, Chen S U, Chao K H, Huang S C, Lee T Y, Yang Y S
Department of Obstetrics and Gynecology, College of Medicine, Hospital National Taiwan University, Taipei, Republic of China.
J Obstet Gynaecol Res. 1996 Oct;22(5):443-50. doi: 10.1111/j.1447-0756.1996.tb01055.x.
The purpose of this study was to evaluate whether the combined treatment of growth hormone (GH) and gonadotropins can improve ovulation stimulation in previously poor responders. Twelve patients who, had suboptimal responses in previous in vitro fertilization cycle were enrolled. They underwent 1 cycle with gonadotropin-releasing hormone analogue (GnRH-a) and gonadotropins and another cycle with GnRH-a, gonadotropins, and GH. Serum gonadotropins, insulin-like growth factor-1 (IGF-1), and sex steroids, including estradiol (E2), progesterone (P4), testosterone, and androstenedione were measured on Day 2 and during ovulation induction. The serum IGF-1 level was higher in the GH cycle. There were no significant differences in the levels of the serum luteinizing hormone, E2, P4, testosterone, and androstenedione between the 2 cycles, so was IGF-1, E2 and P4 in follicular fluid. Co-treatment with GH did not improve the ovarian response. However, the GH cycles had better performance in terms of the number of oocytes fertilized and the pregnancy rate.
本研究的目的是评估生长激素（GH）与促性腺激素联合治疗能否改善既往反应不良者的促排卵效果。纳入了12例在既往体外受精周期中反应欠佳的患者。他们接受了1个周期的促性腺激素释放激素类似物（GnRH-a）和促性腺激素治疗，以及另1个周期的GnRH-a、促性腺激素和GH治疗。在第2天和促排卵期间测定血清促性腺激素、胰岛素样生长因子-1（IGF-1）和性激素，包括雌二醇（E2）、孕酮（P4）、睾酮和雄烯二酮。GH周期的血清IGF-1水平较高。两个周期之间血清黄体生成素、E2、P4、睾酮和雄烯二酮水平无显著差异，卵泡液中的IGF-1、E2和P4水平也无显著差异。GH联合治疗并未改善卵巢反应。然而，GH周期在受精的卵母细胞数量和妊娠率方面表现更好。
