Beppu T
Department of Applied Biological Science, College of Veterinary Medicine, Nihon University, Kanagawa, Japan.
J Ind Microbiol. 1996 Jun;16(6):360-3. doi: 10.1007/BF01570116.
Apparently contrasting approaches, ie genetic engineering and screening of new microorganisms, play essential complementary roles to develop current industrial microbiology. Three topics, production and modification of milk-clotting proteinases by genetic engineering, hormonal control of secondary metabolism in streptomycetes, and screening of bioactive metabolites, are introduced as cases of such a hybrid approach, while symbiotic microorganisms are discussed as an example of the vast terra incognita still remaining for the future microbiology.
表面上截然不同的方法，即基因工程和新型微生物筛选，在推动当前工业微生物学发展中发挥着至关重要的互补作用。本文介绍了三个主题，即通过基因工程生产和改造凝乳蛋白酶、链霉菌次生代谢的激素调控以及生物活性代谢产物的筛选，作为这种混合方法的实例，同时讨论了共生微生物，作为未来微生物学中仍有待探索的广阔未知领域的一个例子。
