Enjoh M, Hashimoto K, Arai S, Shimizu M
Department of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan.
Biosci Biotechnol Biochem. 1996 Nov;60(11):1893-5. doi: 10.1271/bbb.60.1893.
Arphamenine A, an Arg-Phe analog without a peptide bond, has been reported to be a possible inhibitor of the peptide transporter [H. Daniel and S.A. Adibi, FASEB J., 8, 753 (1994)]. The present study demonstrated that arphamenine A is not a real inhibitor, but is a substrate for the transporter, being transported transepithelially under a proton gradient. The substrate specificity of the peptide transporter was wider than expected.
无肽键的精氨酸-苯丙氨酸类似物阿法美宁A据报道可能是肽转运体的抑制剂[H. 丹尼尔和S.A. 阿迪比，《美国实验生物学会联合会杂志》，8，753（1994）]。本研究表明，阿法美宁A并非真正的抑制剂，而是该转运体的底物，在质子梯度下可进行跨上皮转运。肽转运体的底物特异性比预期的更广泛。
