头孢匹罗在高通量膜长期血液透析中的多剂量药代动力学

Multiple-dose pharmacokinetics of cefpirome in long-term hemodialysis with high-flux membranes.

作者信息

Thalhammer F, Schmaldienst S, Elmenyawi I, Atteneder M, Burgmann H, Hollenstein U, Georgopoulos A, Graninger W, Putz D, Rosenkranz A R, Mayer G, Hörl W H, Breyer S

机构信息

Department of Infectious Diseases, University of Vienna, Austria.

出版信息

Clin Pharmacol Ther. 1996 Dec;60(6):645-50. doi: 10.1016/S0009-9236(96)90212-X.

DOI:10.1016/S0009-9236(96)90212-X

PMID:8988066

Abstract

Cefpirome is a cephalosporin eliminated primarily by kidneys that requires dosage reduction in patients with renal failure. The pharmacokinetic parameters were studied in 10 patients with end-stage renal disease who were receiving hemodialysis. Repeated intravenous administration of 2 gm cefpirome three times a week resulted in trough levels of 12.2 +/- 5.4 micrograms/ml and peak serum concentrations of 99.6 +/- 82.1 micrograms/ml. After 3 1/2 hours of hemodialysis with polysulfone high-flux membranes, 62.3% +/- 23.3% of cefpirome was removed. The interdialytic half-life was 9.35 +/- 0.99 hours, and the intradialytic half-life was 2.02 +/- 0.7 hours.

摘要

头孢匹罗是一种主要经肾脏消除的头孢菌素，肾衰竭患者需要减少剂量。对10例接受血液透析的终末期肾病患者的药代动力学参数进行了研究。每周三次重复静脉注射2克头孢匹罗，导致谷浓度为12.2±5.4微克/毫升，血清峰值浓度为99.6±82.1微克/毫升。使用聚砜高通量膜进行3个半小时的血液透析后，62.3%±23.3%的头孢匹罗被清除。透析间期半衰期为9.35±0.99小时，透析期半衰期为2.02±0.7小时。