Ahrens B, Berghöfer A, Wolf T, Müller-Oerlinghausen B
Department of Psychiatry, Freie Universität Berlin, Germany.
J Affect Disord. 1995 Dec 24;36(1-2):43-9. doi: 10.1016/0165-0327(95)00054-2.
One of the strongest predictors of suicide is a suicide attempt in the history of the patient. The question, however, is to what extent age and duration of the illness affects the risk of a suicide attempt. In this study, we examined the course of 310 patients with primary affective disorders before lithium prophylaxis and compared the clinical data of those with and without suicide attempts in their history. In a subgroup of 98 patients with suicide attempts, measures for both suicide attempts and inpatient episodes were investigated. Comparing patients with suicide attempts and those without, we found no difference between duration of illness and number of previous episodes between the two groups. However, those with a suicide attempt in their history had an earlier onset of the illness. In the group of 98 suicide attempters, we found no significant correlation between age and rates for both episodes and suicide attempts, which indicates that these rates were not declining as the illness progressed and the patient aged. Dividing the sample into three different age groups, episode rates and rates of attempted suicide were found to be positively correlated in all age groups, again indicating that as long as episodes occur, the suicide risk does not decline. The results are not in favor of findings which suggest that the risk of attempting suicide might manifest itself primarily in the early course of the illness or that suicide attempts in the early course of illness provide a 'cathartic effect' which leads to a lower risk in the later course of the illness. Rather, the findings support the view that the risk of suicide attempts in recurrent affective disorders is unchanged in all age groups and throughout all stages of untreated illness.
自杀最强的预测因素之一是患者既往有自杀未遂史。然而,问题在于年龄和病程在多大程度上会影响自杀未遂的风险。在本研究中,我们调查了310例原发性情感障碍患者在接受锂盐预防性治疗前的病程,并比较了有和无自杀未遂史患者的临床资料。在一个包含98例有自杀未遂史患者的亚组中,我们对自杀未遂和住院发作的相关指标进行了研究。比较有自杀未遂史的患者和无自杀未遂史的患者,我们发现两组之间在病程和既往发作次数上没有差异。然而,有自杀未遂史的患者发病更早。在98例自杀未遂者的组中,我们发现年龄与发作次数和自杀未遂率之间没有显著相关性,这表明这些比率并不会随着病程进展和患者年龄增长而下降。将样本分为三个不同年龄组后,发现发作率和自杀未遂率在所有年龄组中均呈正相关,这再次表明只要有发作,自杀风险就不会下降。这些结果并不支持以下观点,即自杀未遂风险可能主要在疾病早期表现出来,或者疾病早期的自杀未遂具有“宣泄效应”,从而导致疾病后期风险降低。相反,这些发现支持这样一种观点,即复发性情感障碍患者的自杀未遂风险在所有年龄组以及未经治疗疾病的所有阶段都是不变的。