Song Joo Yun, Yu Han Young, Kim Se Hyun, Hwang Samuel S-H, Cho Hyun-Sang, Kim Yong Sik, Ha Kyooseob, Ahn Yong Min
Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea.
J Nerv Ment Dis. 2012 Nov;200(11):978-84. doi: 10.1097/NMD.0b013e3182718a07.
We compared the characteristics of patients with bipolar disorder with and without a history of suicide attempts to identify the risk factors of suicide in this disorder. Among 212 patients with bipolar disorder, 44 (21.2%) patients had histories of suicide attempts. Suicide attempters were younger and more likely to be diagnosed with bipolar II. The variables that differentiated those who did from those who did not attempt suicide included age at first contact, lifetime history of antidepressant use, major depressive episode, mixed episode, auditory hallucinations, rapid cycling, the number of previous mood episodes, age of first depressive episode, and age of first psychotic symptoms. Strong predictors of suicide attempts were younger age at onset, lifetime history of auditory hallucinations, and history of antidepressant use. Antecedent depressive episodes and psychotic symptoms predicted the first suicide attempt in patients with bipolar disorder. This study could help clinicians to understand the major risk factors of suicidal behavior in bipolar disorder.
我们比较了有和没有自杀未遂史的双相情感障碍患者的特征，以确定该疾病中自杀的风险因素。在212例双相情感障碍患者中，44例（21.2%）有自杀未遂史。自杀未遂者更年轻，且更有可能被诊断为双相II型。区分有自杀未遂和无自杀未遂患者的变量包括首次接触时的年龄、终生使用抗抑郁药史、重度抑郁发作、混合发作、幻听、快速循环、既往情绪发作次数、首次抑郁发作年龄和首次精神病性症状出现年龄。自杀未遂的强预测因素是发病时年龄较小、有终生幻听史和使用抗抑郁药史。前驱抑郁发作和精神病性症状可预测双相情感障碍患者的首次自杀未遂。本研究有助于临床医生了解双相情感障碍患者自杀行为的主要风险因素。
