Johri A K, Dua M, Tuteja D, Saxena R, Saxena D M, Lal R
Department of Zoology, University of Delhi, India.
FEMS Microbiol Rev. 1996 Dec;19(2):69-84. doi: 10.1111/j.1574-6976.1996.tb00254.x.
Hexachlorocyclohexane (HCH) is an organochlorine insecticide which has been banned in technologically advanced countries. However, it is still in use in tropical countries for mosquito control and thus new areas continue to be contaminated. Anaerobic degradation of HCH isomers have been well documented but until recently there have been only a few reports on aerobic microbial degradation of HCH isomers. The isolation of these microbes made it possible to design experiments for the cloning of the catabolic genes responsible for degradation. We review the microbial degradation of HCH isomers coupled with the genetic manipulations of the catabolic genes. The first part discusses the persistence of residues in the environment and microbial degradation while the second part gives an account of the genetic manipulations of catabolic genes involved in the degradation.
六氯环己烷（HCH）是一种有机氯杀虫剂，在技术先进的国家已被禁用。然而，它仍在热带国家用于控制蚊虫，因此新的区域不断受到污染。HCH异构体的厌氧降解已有充分记载，但直到最近，关于HCH异构体需氧微生物降解的报道还很少。这些微生物的分离使得设计实验克隆负责降解的分解代谢基因成为可能。我们综述了HCH异构体的微生物降解以及分解代谢基因的遗传操作。第一部分讨论了残留物在环境中的持久性和微生物降解，而第二部分则介绍了参与降解的分解代谢基因的遗传操作。
