Druid H, Holmgren P
Department of Forensic Medicine, University Hospital, Linköping, Sweden.
J Forensic Sci. 1997 Jan;42(1):79-87.
A compilation of postmortem femoral blood concentrations of drugs is presented. The samples are collected from cases in which the cause of death was: A) certified intoxication by one substance alone, B) certified intoxication by more than one substance and/or alcohol, and C) certified other cause of death without incapacitation due to drugs. The concentrations were compared with blood concentrations detected in suspected drugged drivers (D), and with previously published fatal and therapeutic concentrations. The special features of this compilation are: 1) exclusively femoral blood concentrations are quoted, 2) all analyses are based on samples handled according to a standardized, quality-controlled procedure, 3) two control groups are included, and 4) one-substance-only intoxications are separated from other intoxications. The material is based on a selection of 15,800 samples sent to the Department of Forensic Chemistry in Linköping, Sweden, during 1992 to 1995 from the six forensic pathology units in Sweden, and the list includes 83 drugs. The compilation includes drugs, where previously published data are scarce. Furthermore, the data gathered from cases with other cause of death than intoxication (group C) constitute a new kind of reference information, which probably offers a better estimate of obviously non fatal levels in postmortem blood than any compilation of therapeutic concentrations in living subjects. The possible factors influencing postmortem drug concentrations are discussed.
本文呈现了一组死后股静脉血中药物浓度的数据。样本取自以下几种死因的案例：A）经证实由单一物质导致的中毒；B）经证实由多种物质和/或酒精导致的中毒；C）经证实因其他死因死亡，且不存在因药物导致的身体机能丧失。这些浓度与在疑似药物影响下的驾驶员（D）中检测到的血药浓度，以及先前公布的致死浓度和治疗浓度进行了比较。该数据集的特点包括：1）仅引用股静脉血浓度；2）所有分析均基于按照标准化、质量控制程序处理的样本；3）纳入了两个对照组；4）单一物质中毒与其他中毒情况分开统计。数据来源于1992年至1995年间从瑞典六个法医病理单位送往瑞典林雪平法医化学系的15800份样本，列表中包含83种药物。该数据集涵盖了此前公布数据较少的药物。此外，从非中毒死因案例（C组）收集的数据构成了一种新的参考信息，相较于任何关于活体治疗浓度的数据集，它可能能更好地估计死后血液中明显的非致死水平。文中还讨论了影响死后药物浓度的可能因素。
