Chen Q, Wilson B C, Shetty S D, Patterson M S, Cerny J C, Hetzel F W
HealthONE, Denver, Colorado 80218, USA.
Radiat Res. 1997 Jan;147(1):86-91. doi: 10.2307/3579447.
The optical absorption and transport scattering coefficients of normal prostate tissue have been measured in vivo in dogs. The measurements were made at 630 nm before and during treatment by Photofin photodynamic therapy using interstitial optical fiber fluence-rate detectors. Corresponding measurements were made ex vivo, at 1 week after treatment, in the contralateral lobe. The optical properties were derived by applying a diffusion theory model to the fluence rates measured at two different source-detector fiber distances. While the in vivo pretreatment and in vivo contralateral post-treatment absorption and scattering values are self-consistent and in agreement with published data, significant changes were observed in the light fluence rates, and hence in the derived optical properties, during light irradiation. The possible causes of such changes are considered, and the implications for light dosimetry in photodynamic therapy are discussed.
已在犬体内测量了正常前列腺组织的光吸收系数和输运散射系数。这些测量是在使用间质光纤注量率探测器进行光动力疗法治疗之前和治疗期间，于630nm波长下进行的。在治疗后1周，对侧叶进行了离体相应测量。通过将扩散理论模型应用于在两个不同源 - 探测器光纤距离处测量的注量率来推导光学特性。虽然体内预处理以及体内对侧叶治疗后的吸收和散射值是自洽的，并且与已发表的数据一致，但在光照射期间，光注量率出现了显著变化，因此推导的光学特性也发生了变化。考虑了这种变化的可能原因，并讨论了其对光动力疗法中光剂量学的影响。
