Sharma U K, Song H, Casella S J, Schwartz D H
Department of Molecular Microbiology and Immunology, School of Public Health an d Hygiene, Johns Hopkins University, Baltimore, Maryland 21205, USA.
AIDS Res Hum Retroviruses. 1997 Jan 1;13(1):105-10. doi: 10.1089/aid.1997.13.105.
Insulin-like growth factor type I (IGF-I) has been used as a treatment for cachexia in adults with AIDS and has been reported to show inhibitory activity against HIV-1IIIB in cord blood mononuclear cells (CBMCs) in vitro at low-concentration (1%) fetal bovine serum (FCS). We evaluated the effect of IGF-I on MN, IIIB, and BaL strains, as well as on a patient isolate of HIV-1 in CBMCs and adult peripheral blood mononuclear cells (PBMCs). IGF-I failed to show any inhibitory effect on HIV replication in CBMCs or adult PBMCs under various culture conditions. In contrast to an earlier report of an antiviral effect, IGF-I augmented HIV-1 replication in PHA-stimulated PBMCs maintained in a low concentration of FCS.
胰岛素样生长因子I型（IGF-I）已被用于治疗成年艾滋病患者的恶病质，并且有报道称在低浓度（1%）胎牛血清（FCS）条件下，其在体外对脐血单个核细胞（CBMCs）中的HIV-1IIIB具有抑制活性。我们评估了IGF-I对CBMCs和成人外周血单个核细胞（PBMCs）中MN、IIIB和BaL毒株以及一株HIV-1患者分离株的影响。在各种培养条件下，IGF-I在CBMCs或成人PBMCs中均未显示出对HIV复制的任何抑制作用。与之前关于抗病毒作用的报道相反，在低浓度FCS条件下培养的PHA刺激的PBMCs中，IGF-I增强了HIV-1的复制。
