Feldmeier J J, Heimbach R D, Davolt D A, Court W S, Stegmann B J, Sheffield P J
Department of Radiation Oncology, Wayne State University, Detroit, Michigan, USA.
Undersea Hyperb Med. 1996 Dec;23(4):205-13.
Radiation therapy is often utilized as adjunctive or primary treatment for malignancies of the abdomen and pelvis. Radiation complications are infrequent, but can be life threatening or significantly diminish the quality of life. Radiation necrosis is an approved indication for hyperbaric oxygen (HBO2). Previous publications have reported results in treating delayed radiation injuries involving many sites. This paper reports the experience of a single physician group in treating delayed injuries of the abdomen and/or pelvis. Forty-four such patients have been treated since 1979. Of the 41 patients available for follow up, 26 have healed; 6 failed to heal; and 9 patients had an inadequate course of therapy (fewer than 20 treatments). Especially encouraging was the resolution of fistulae in six of eight patients with only three requiring surgery for closure. Overall, the success rate in patients receiving at least 20 HBO2 treatments was 81%. Hyperbaric oxygen is a useful adjunct in treatment of delayed radiation injuries of the pelvis and abdomen.
放射治疗常被用作腹部和盆腔恶性肿瘤的辅助或主要治疗方法。放射治疗并发症并不常见，但可能危及生命或显著降低生活质量。放射性坏死是高压氧（HBO₂）的一项已获批适应症。既往出版物报道了治疗涉及多个部位的迟发性放射损伤的结果。本文报告了一个医生团队治疗腹部和/或盆腔迟发性损伤的经验。自1979年以来，共治疗了44例此类患者。在可进行随访的41例患者中，26例已愈合；6例未愈合；9例治疗疗程不足（少于20次治疗）。特别令人鼓舞的是，8例瘘管患者中有6例瘘管得以愈合，其中仅3例需要手术闭合。总体而言，接受至少20次HBO₂治疗的患者成功率为81%。高压氧是治疗盆腔和腹部迟发性放射损伤的一种有用辅助手段。
