Buschmann J, Leppla-Wollsiffer G, Nemeth N, Nelson K, Kirsten R
Department of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt, Germany.
Headache. 1996 Nov-Dec;36(10):586-8. doi: 10.1046/j.1526-4610.1996.3610586.x.
This study was designed to investigate vasopressin receptor status (Bmax and Kd) on platelets, vasopressin plasma levels, and vasopressin-induced platelet aggregation in migraine patients (21 females and 6 males) during a headache-free interval and in a matched control group. In the migraine group, Bmax was significantly higher (P = 0.02) at 53.9 +/- 20.6 fmol/mg than in the control group (36.8 +/- 21.0 fmol/mg). A correlation between Bmax and high or low sensitivity to vasopressin as an aggregator was evident in the control group, but not in the migraine group. No differences in Kd or in plasma levels of vasopressin between the migraine and control group were apparent. Men in both groups were much less sensitive to vasopressin as a platelet aggregator than were women (P < 0.01). Whether the higher Bmax in the migraine group is a reflection of temporarily higher vasopressin levels during headache or reflects a primary increase in sensitivity to vasopressin, remains to be clarified. The higher sensitivity of platelets (as a model for vessel wall receptors) from women may indicate why many more women than men suffer from migraine. Since the Bmax of the vasopressin receptor on platelets from migraine patients is increased compared to controls, treating migraine headache with vasopressin may deserve more attention.
本研究旨在调查偏头痛患者（21名女性和6名男性）在无头痛间期以及匹配的对照组中血小板上血管加压素受体状态（最大结合容量Bmax和解离常数Kd）、血管加压素血浆水平以及血管加压素诱导的血小板聚集情况。在偏头痛组中，Bmax为53.9±20.6 fmol/mg，显著高于对照组（36.8±21.0 fmol/mg，P = 0.02）。在对照组中，Bmax与对血管加压素作为聚集剂的高敏感性或低敏感性之间存在明显相关性，但在偏头痛组中未观察到这种相关性。偏头痛组和对照组之间在Kd或血管加压素血浆水平上没有明显差异。两组中的男性作为血小板聚集剂对血管加压素的敏感性均远低于女性（P < 0.01）。偏头痛组中较高的Bmax是反映头痛期间血管加压素水平暂时升高，还是反映对血管加压素敏感性的原发性增加，仍有待阐明。女性血小板（作为血管壁受体的模型）具有较高的敏感性，这可能解释了为什么患偏头痛的女性比男性多得多。由于偏头痛患者血小板上血管加压素受体的Bmax高于对照组，因此使用血管加压素治疗偏头痛可能值得更多关注。
