Jallon P
Unité d'Epileptologie clinique, Hôpital Cantonal, Genève.
Presse Med. 1996 Dec 7;25(38):1876-80.
Based on more than one hundred epidemiological studies we evaluated the frequency of epileptic seizures and epilepsy itself. Worldwide, there appears to be unequal distribution of disease incidence and prevalence. It seems that the incidence of epilepsy in developing countries would be greater than that in the industrialized world and that the differences in prevalence observed between the developing and the industrialized countries could be epidemiologically significant. Once the methodological biases that might account for these differences have been eliminated, it is probable that the differences in incidence and prevalence could be explained by specific risk factors. Particular regional distribution of the disease would then reflect local risk factors and, therefore represent epidemiological markers of particular regional or endemic infections, hereditary predispositions, early interventions during management of childbirth and childhood development or even the natural course of the disease.
基于一百多项流行病学研究，我们评估了癫痫发作的频率以及癫痫本身。在全球范围内，疾病的发病率和患病率分布似乎并不均衡。发展中国家的癫痫发病率似乎高于工业化国家，而且发展中国家和工业化国家之间观察到的患病率差异在流行病学上可能具有重要意义。一旦消除了可能导致这些差异的方法学偏差，发病率和患病率的差异很可能可以由特定的风险因素来解释。该疾病的特定区域分布将反映当地的风险因素，因此代表特定区域或地方性感染、遗传易感性、分娩和儿童发育管理期间的早期干预措施甚至疾病自然病程的流行病学标志。
