Maina J M, Aluoch J R
Division of Medicine, Kenyatta National Hospital, Nairobi, Kenya.
East Afr Med J. 1996 Sep;73(9):568-70.
From July 1990 to January 1991 we studied platelet functions in 55 indigenous Kenyan patients (23 males and 32 females) with sickle cell anaemia (SCA) in steady state (SCASS) and in 20 (11 males and 9 females) SCA patients in vaso-occlusive sickle cell crisis (VSCC). A control group of 50 healthy (23 males and 27 females) individuals matched for age and sex was also studied. Platelet aggregation time to ADP in SCASS (57.2 +/- 39.1) and in VSCC (31 +/- 11.1) were more prolonged (p < 0.05) compared to controls (12.7 +/- 5.2). It was also significantly more prolonged (p < 0.05) in VSCC than in SCASS. Platelet adhesiveness time was 31.1 +/- 13.7 seconds in SCASS, 30.9 +/- 11.1 in VSCC, and 37.7 +/- 13.0 in controls and was significantly lower in both SCA groups (p < 0.05) but there was no significant difference between the two SCA groups themselves. Clot retraction was 52.8 +/- 6.9 in SCASS, 53.6 +/- 10.7 in VSCC, and 45.9 +/- 8 in controls and was significantly higher in both SCA groups than in controls (p < 0.05). There was no significant difference between the two SCA groups themselves. We conclude that platelet function is deranged in indigenous Kenyan patients with SCA.
1990年7月至1991年1月，我们对55名处于稳定状态的镰状细胞贫血（SCA）肯尼亚本土患者（23名男性和32名女性）以及20名处于血管闭塞性镰状细胞危象（VSCC）的SCA患者（11名男性和9名女性）的血小板功能进行了研究。还研究了一个由50名年龄和性别匹配的健康个体（23名男性和27名女性）组成的对照组。与对照组（12.7±5.2）相比，SCASS组（57.2±39.1）和VSCC组（31±11.1）的血小板对ADP的聚集时间延长更明显（p<0.05）。VSCC组的聚集时间也显著长于SCASS组（p<0.05）。SCASS组的血小板黏附时间为31.1±13.7秒，VSCC组为30.9±11.1秒，对照组为37.7±13.0秒，两个SCA组的血小板黏附时间均显著低于对照组（p<0.05），但两个SCA组之间无显著差异。SCASS组的血块收缩率为52.8±6.9，VSCC组为53.6±10.7，对照组为45.9±8，两个SCA组的血块收缩率均显著高于对照组（p<0.05）。两个SCA组之间无显著差异。我们得出结论，肯尼亚本土SCA患者的血小板功能紊乱。
