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[亚硝酸钠与全身照射对动物组织联合作用的电子顺磁共振研究]

[An EPR study of the joint action of sodium nitrite and whole-body irradiation on animal tissues].

作者信息

Kudriavtsev M E, Dmitrieva O N, Kuropteva Z V

出版信息

Izv Akad Nauk Ser Biol. 1996 Jul-Aug(4):453-9.

PMID:8991528
Abstract

Changes in metabolic paramagnetic centers of the liver, kidney, spleen, brain and heart tissues, and blood after sodium nitrite intraperitoneal administration irradiation, or combined action of sodium nitrite and irradiation on mice, were studied using the EPR method. It was shown that irradiation of mice after sodium nitrite administration enhanced the effects induced by sodium nitrite alone: the levels of nitrosyl complexes Heme-NO in the tissues, cytochrome P-450 inhibition, and MetHb were higher.

摘要

采用电子顺磁共振(EPR)方法研究了亚硝酸钠腹腔注射、辐照或亚硝酸钠与辐照联合作用于小鼠后,肝脏、肾脏、脾脏、脑组织和心脏组织以及血液中代谢顺磁中心的变化。结果表明,亚硝酸钠给药后对小鼠进行辐照增强了单独使用亚硝酸钠所诱导的效应:组织中亚硝酰复合物血红素-NO的水平、细胞色素P-450的抑制作用以及高铁血红蛋白水平更高。

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