Jørgensen H, Bukh A, Hokland P, Ellegaard J, Madsen P S, Hokland M
Institut for medicinsk mikrobiologi, Arhus Universitet, Barholin Bygningen, Arhus.
Nord Med. 1996 Dec;111(10):344-7.
ABMT (autologous bone marrow transplantation) is being increasingly used in the treatment of malignant diseases, including the acute leukaemias. Although ABMT seems to be superior to conventional chemotherapy in terms of disease-free survival, an unacceptably high frequency of relapse after ABMT remains a major problem. As such relapse may be due to malignant cells in the graft or residual malignant cells surviving in the patient after preconditioning therapy, it is essential to be able to detect and eradicate residual malignant cells. The article presents a review of available methods for the detection of minimal residual disease in conjunction with ABMT, especially regarding their relative sensitivity and specificity.
自体骨髓移植（ABMT）越来越多地用于治疗包括急性白血病在内的恶性疾病。尽管在无病生存率方面，自体骨髓移植似乎优于传统化疗，但自体骨髓移植后复发频率高得令人难以接受，仍然是一个主要问题。由于这种复发可能是由于移植物中的恶性细胞或预处理治疗后患者体内存活的残留恶性细胞所致，因此能够检测并根除残留恶性细胞至关重要。本文综述了与自体骨髓移植相关的检测微小残留病的现有方法，尤其涉及它们的相对敏感性和特异性。
