Levy B I
INSERM Unit 141, IFR Circulation Lariboisière, Paris, France.
Prostaglandins Leukot Essent Fatty Acids. 1996 Jan;54(1):39-43. doi: 10.1016/s0952-3278(96)90079-4.
In hypertensive patients, the buffering function of large arteries is constantly altered, due to modifications in the viscoelastic properties of the arterial wall. Several in vivo models of the arterial circulation have been described to determine arterial compliance in animals and humans. The pressure dependency of arterial compliance is the main difficulty in evaluating the mechanical properties of large arteries in hypertension and establishing whether reduced arterial compliance is the simple mechanical consequence of the blood pressure elevation or reflects intrinsic alterations of the arterial wall. In comparison with the normotensive population, the carotid arterial wall is stiffer in hypertensive rats and humans, due to abnormalities in both the structural and the functional components. Interestingly, the presence of an intact and normal endothelium greatly influence vasomotor tone. The pathways by which the intrinsic modifications of the arterial wall may be reversed following drug treatment remain difficult to delineate. However, such considerations are clearly of importance for antihypertensive therapy, the goal of which may be not only the reduction of blood pressure but also improvement of the status of the hypertensive abnormalities of the arterial system.
在高血压患者中，由于动脉壁粘弹性特性的改变，大动脉的缓冲功能不断变化。已经描述了几种动脉循环的体内模型来确定动物和人类的动脉顺应性。动脉顺应性的压力依赖性是评估高血压患者大动脉力学特性以及确定动脉顺应性降低是血压升高的简单力学后果还是反映动脉壁内在改变的主要困难。与血压正常人群相比，高血压大鼠和人类的颈动脉壁更僵硬，这是由于结构和功能成分均存在异常。有趣的是，完整且正常的内皮的存在极大地影响血管舒缩张力。药物治疗后动脉壁内在改变可能被逆转的途径仍难以描述。然而，这些考虑对于抗高血压治疗显然很重要，其目标可能不仅是降低血压，还包括改善动脉系统高血压异常的状况。
