Pollack M H, Worthington J J, Otto M W, Maki K M, Smoller J W, Manfro G G, Rudolph R, Rosenbaum J F
Anxiety Disorders Program, Massachusetts General Hospital, Boston 02114, USA.
Psychopharmacol Bull. 1996;32(4):667-70.
Venlafaxine has demonstrated efficacy for depression, and recent reports and clinical experience suggest that it may be effective for the treatment of anxiety disorders as well. We present what we believe are the first data from a controlled study designed to test the efficacy of venlafaxine for the treatment of panic disorder. There were 25 patients enrolled at one site of a five-center study; 13 received venlafaxine and 12 received placebo. There were more dropouts for placebo than for venlafaxine (8/12 vs. 2/13) in this 8-week acute trial. Patients treated with venlafaxine experienced significantly greater global improvement than those on placebo and exhibited trends toward greater improvement on anxiety and depression symptoms as assessed by the Hamilton rating scales. These data encourage further evaluation of venlafaxine for the treatment of panic disorder.
文拉法辛已被证明对抑郁症有效，最近的报道和临床经验表明，它可能对焦虑症的治疗也有效。我们展示了我们认为是第一项来自对照研究的数据，该研究旨在测试文拉法辛治疗惊恐障碍的疗效。在一项五中心研究的一个地点招募了25名患者；13名接受文拉法辛治疗，12名接受安慰剂治疗。在这项为期8周的急性试验中，接受安慰剂治疗的患者比接受文拉法辛治疗的患者有更多的退出者（8/12对2/13）。接受文拉法辛治疗的患者在总体改善方面比接受安慰剂治疗的患者有显著更大的改善，并且根据汉密尔顿评定量表评估，在焦虑和抑郁症状方面有更大改善的趋势。这些数据鼓励对文拉法辛治疗惊恐障碍进行进一步评估。
