Amirghofran Z, Ghaderi A A
Department of Microbiology and Immunology, Medical School, Shiraz University of Medical Science, Iran.
Roum Arch Microbiol Immunol. 1995 Oct-Dec;54(4):265-70.
CD38 is a 45 KD glycoprotein which is mainly expressed on early lymphoid progenitors and plasma cells. Role and function of CD38 on thymocytes and plasma cells has not yet been elucidated. By cross-linking of CD38 molecules using a specific monoclonal antibody on thymocytes and a neoplastic T cell line (Jurkat), it was shown that percentage of HLA-DR and IL-2R molecules is significantly upregulated. Moreover, CD11a and CD18 were among two adhesion molecules which showed a sharp increase in expression, whereas no changes on expression of CD11b, CD44 and CD54 were detected. Spontaneous proliferation of Jurkat cell line after addition of different concentrations of CD38 monoclonal antibody was unchanged.
CD38是一种45千道尔顿的糖蛋白，主要表达于早期淋巴祖细胞和浆细胞。CD38在胸腺细胞和浆细胞上的作用及功能尚未阐明。通过使用特异性单克隆抗体对胸腺细胞和肿瘤性T细胞系（Jurkat）上的CD38分子进行交联，结果显示HLA-DR和IL-2R分子的百分比显著上调。此外，CD11a和CD18是表达显著增加的两种黏附分子，而未检测到CD11b、CD44和CD54表达的变化。添加不同浓度的CD38单克隆抗体后，Jurkat细胞系的自发增殖未发生改变。
