Scheule A M, Jurmann M J, Wendel H P, Häberle L, Eckstein F S, Ziemer G
Department of Surgery, Eberhard-Karls-University, Tuebingen, Germany.
Ann Thorac Surg. 1997 Jan;63(1):242-4. doi: 10.1016/s0003-4975(96)01062-4.
We report a case of severe anaphylactic shock during a cardiac operation that occurred as a consequence of aprotinin readministration in the presence of preformed aprotinin-specific antibodies. Both immunoglobulin G (3 hours) and immunoglobulin E (5 minutes) antibody levels dropped early after the clinical event. Despite their possibly limited clinical significance, we still recommend the conductance of specific antibody screening tests before readministration of aprotinin.
我们报告了一例心脏手术期间发生的严重过敏性休克病例，该病例是在预先存在抑肽酶特异性抗体的情况下再次使用抑肽酶所致。临床事件发生后，免疫球蛋白G（3小时）和免疫球蛋白E（5分钟）抗体水平均早期下降。尽管它们的临床意义可能有限，但我们仍建议在再次使用抑肽酶之前进行特异性抗体筛查试验。
