Wynn T A
Immunobiology Section, National Institutes of Health, Bethesda, Maryland 20892, USA.
Ann N Y Acad Sci. 1996 Oct 25;797:191-5. doi: 10.1111/j.1749-6632.1996.tb52960.x.
The data presented here clearly demonstrate that IL-12 can act as an adjuvant, suppressing both granuloma formation and fibrosis induced after natural schistosome infection. Recently, we showed that IL-12 can increase protective immunity provided by an attenuated larval schistosome vaccine as well. In both cases the vaccines appear to suppress in large part the parasite-induced Th2 responses. Thus, the use of cytokines as adjuvants offers a rational approach for immunomodulation when the effector mechanism of a particular vaccine is known. Clearly, IL-12 has enormous potential for modulating the outcome of immunization and may have broad application in preventing a variety of different infectious diseases.
此处呈现的数据清楚地表明，白细胞介素-12可作为一种佐剂，抑制自然感染血吸虫后诱导形成的肉芽肿和纤维化。最近，我们还表明白细胞介素-12可增强减毒血吸虫幼虫疫苗所提供的保护性免疫。在这两种情况下，疫苗似乎在很大程度上抑制了寄生虫诱导的Th2反应。因此，当特定疫苗的效应机制已知时，使用细胞因子作为佐剂为免疫调节提供了一种合理的方法。显然，白细胞介素-12在调节免疫结果方面具有巨大潜力，可能在预防多种不同传染病方面有广泛应用。
