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Pituitary adenylate cyclase-activating polypeptide induces gene expression of the catecholamine synthesizing enzymes, tyrosine hydroxylase, and dopamine beta-hydroxylase in cultured porcine adrenal medullary chromaffin cells.

作者信息

Isobe K, Yukimasa N, Nakai T, Takuwa Y

机构信息

Department of Clinical Pathology, University of Tsukuba, Ibaraki, Japan.

出版信息

Ann N Y Acad Sci. 1996 Dec 26;805:464-9. doi: 10.1111/j.1749-6632.1996.tb17504.x.

DOI:10.1111/j.1749-6632.1996.tb17504.x
PMID:8993424
Abstract
摘要

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1
Pituitary adenylate cyclase-activating polypeptide induces gene expression of the catecholamine synthesizing enzymes, tyrosine hydroxylase, and dopamine beta-hydroxylase in cultured porcine adrenal medullary chromaffin cells.
Ann N Y Acad Sci. 1996 Dec 26;805:464-9. doi: 10.1111/j.1749-6632.1996.tb17504.x.
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Pituitary adenylate cyclase-activating polypeptide induces gene expression of the catecholamine synthesizing enzymes, tyrosine hydroxylase and dopamine beta hydroxylase, through 3',5'-cyclic adenosine monophosphate- and protein kinase C-dependent mechanisms in cultured porcine adrenal medullary chromaffin cells.垂体腺苷酸环化酶激活多肽通过3'，5'-环磷酸腺苷和蛋白激酶C依赖性机制，诱导培养的猪肾上腺髓质嗜铬细胞中儿茶酚胺合成酶、酪氨酸羟化酶和多巴胺β羟化酶的基因表达。
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Enhanced cAMP production mediates the stimulatory action of pituitary adenylate cyclase activating polypeptide (PACAP) on in vitro catecholamine secretion from bovine adrenal chromaffin cells.增强的环磷酸腺苷（cAMP）生成介导了垂体腺苷酸环化酶激活多肽（PACAP）对牛肾上腺嗜铬细胞体外儿茶酚胺分泌的刺激作用。
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Pituitary adenylate cyclase activating polypeptide (PACAP) regulates expression of catecholamine biosynthetic enzyme genes in bovine adrenal chromaffin cells.垂体腺苷酸环化酶激活多肽（PACAP）调节牛肾上腺嗜铬细胞中儿茶酚胺生物合成酶基因的表达。
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Pituitary adenylate cyclase-activating polypeptide (PACAP) can act as determinant of the tyrosine hydroxylase phenotype of dopaminergic cells during retina development.垂体腺苷酸环化酶激活多肽（PACAP）在视网膜发育过程中可作为多巴胺能细胞酪氨酸羟化酶表型的决定因素。
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Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on tyrosine hydroxylase gene expression in the rat adrenal medulla.垂体腺苷酸环化酶激活肽（PACAP）对大鼠肾上腺髓质中酪氨酸羟化酶基因表达的影响。
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Ca(2+)-dependent stimulatory effect of pituitary adenylate cyclase-activating polypeptide on catecholamine secretion from cultured porcine adrenal medullary chromaffin cells.垂体腺苷酸环化酶激活多肽对培养的猪肾上腺髓质嗜铬细胞儿茶酚胺分泌的钙离子依赖性刺激作用。
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