Währborg P, Emanuelsson H
Division of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden.
Coron Artery Dis. 1996 Nov;7(11):823-9.
The Cardiac Health Profile (CHP) is a new questionnaire for assessing health-related quality of life of patients with cardiovascular diseases. It consists of three parts assessed as follows: the degree of angina pectoris (the CCS scale), the quality of life and subjective scoring of psychosocial 'cost-benefit'. Parts II and III of the questionnaire are based on visual analogous scales and consist of 16 and two questions, respectively, covering nine areas. This quality of life questionnaire has been tested for reliability, validity and sensitivity.
Eighty consecutive patients with angina pectoris, who were waiting for coronary angiography, were enrolled in the study. Four sets of data were deleted since the respondents were not able to fill in the forms correctly. Fifty-one healthy volunteers constituted a control group.
Reliability was assessed by a 'test and retest' method. The resulting correlation coefficient was 0.927 (P = 0.0009). Internal consistency was studied by applying Cronbach's alpha. The internal alpha-coefficient was 0.89. Concurrent validity was studied by comparing the outcome in the Nottingham Profile with the CHP. The intercorrelation indicated good concurrent validity (r = 0.753, P = 0.0001). The construct validity was assessed by performing a factor analysis. The sensitivity was assessed in three ways: analysis of kurtosis, comparison of the group of angina pectoris patients with a healthy control group and by comparing CHP results before a standard intervention (coronary artery bypass grafting) and after. The CHP showed in all of these ways a good sensitivity with statistically significant differences between angina patients and the control group (P < 0.0001). A significant improvement in health-related quality of life was also found after coronary artery bypass grafting compared with before (P = 0.02).
The CHP has been found to be reliable, valid and sensitive and the present findings encourage use of the questionnaire in clinical trials for its further development.
心脏健康状况问卷（CHP）是一种用于评估心血管疾病患者健康相关生活质量的新问卷。它由三个部分组成，评估方式如下：心绞痛程度（加拿大心血管学会分级量表）、生活质量以及心理社会“成本效益”的主观评分。问卷的第二部分和第三部分基于视觉模拟量表，分别由16个和2个问题组成，涵盖九个领域。这份生活质量问卷已经过可靠性、有效性和敏感性测试。
连续纳入80例等待冠状动脉造影的心绞痛患者参与研究。由于应答者无法正确填写表格，删除了四组数据。51名健康志愿者组成对照组。
通过“重测”法评估可靠性。所得相关系数为0.927（P = 0.0009）。应用克朗巴哈系数研究内部一致性。内部α系数为0.89。通过将诺丁汉健康状况问卷的结果与CHP进行比较来研究同时效度。相互关联表明具有良好的同时效度（r = 0.753，P = 0.0001）。通过进行因子分析评估结构效度。从三个方面评估敏感性：峰度分析、将心绞痛患者组与健康对照组进行比较以及比较标准干预（冠状动脉搭桥术）前后的CHP结果。CHP在所有这些方面均显示出良好的敏感性，心绞痛患者与对照组之间存在统计学显著差异（P < 0.0001）。与冠状动脉搭桥术前相比，术后健康相关生活质量也有显著改善（P = 0.02）。
已发现CHP具有可靠性、有效性和敏感性，目前的研究结果鼓励在临床试验中使用该问卷以进一步开发。
