[Sensitivity of the cholinoreceptive membrane of Lymnaea stagnalis neurons to mono- and bisquaternary ammonium compounds].

The depolarizing potency of polymethylene-bis-trimethylammonium and alkyl-trimenthylammonium compounds with 3-10 methylene groups was studied on the identified giant central neurons of gastropod mollusc Limnaea stagnalis using intracellular microelectrode technique. The bisquaternary salts with 4-7 methylene groups were inactive while the mononitrogen analogues showed cholinomimetic activity. The similar results were obtained by other authors on Vertebrate skeletal muscles with substances studied. The possible explanations of this fact are suggested.