Majesky M W, Dong X R, Topouzis S
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
P R Health Sci J. 1996 Sep;15(3):187-91.
Clear differences exist in the incidence and severity of atherosclerotic plaques that arise in different segments of the arterial tree. Aortic homograft transplant experiments in dogs showed that the greater incidence of plaque formation in the abdominal versus the thoracic aorta was due to intrinsic differences in the cell populations in these two segments rather than to hemodynamic factors. What is the basis for SMC diversity within a common vessel wall? Recent lineage analysis studies in the avian and mammalian embryo indicate that two distinct SMC lineages contribute to the formation of the major elastic outflow arteries including the aorta. A mixture of unique SMC types of diverse developmental lineages within a common vessel wall raises new questions about the potential for SMC type-specific responses to growth factors and cytokines involved in human atherosclerosis and restenosis.
动脉树不同节段出现的动脉粥样硬化斑块在发生率和严重程度上存在明显差异。犬的主动脉同种异体移植实验表明，腹主动脉与胸主动脉相比，斑块形成的发生率更高，这是由于这两个节段细胞群体的内在差异，而非血流动力学因素。同一血管壁内平滑肌细胞多样性的基础是什么？最近对鸟类和哺乳动物胚胎的谱系分析研究表明，两个不同的平滑肌细胞谱系有助于形成包括主动脉在内的主要弹性流出动脉。同一血管壁内不同发育谱系的独特平滑肌细胞类型混合，引发了关于平滑肌细胞对参与人类动脉粥样硬化和再狭窄的生长因子和细胞因子产生类型特异性反应可能性的新问题。
