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[鼠疫杆菌修复缺陷型突变体对物理和化学因子作用的敏感性]

[Sensitivity of repair-defective mutants of the plague microbe to the action of physical and chemical agents].

作者信息

Temiralieva G A, Aĭkimbaev A M, Kondrat'eva O V, Isin Zh M

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1977 Jun(6):74-7.

PMID:899436
Abstract

By the character of the sensitivity of UV-irradiation, to N-methyl-N'-nitro-N-nitrosoguanidine, 5-bromuracil, mitomycin C, crystalviolet, and by the capacity to restore phage injuries the 1435-A and 1435-24 mutants were referred to the uvr-hcr-, 17 mutant--to the uvr-hcr+, and 35 mutant--to lon genotype. As a result of UV irradiation the experimental strains formed heteromorphic forms of bacteria, spindle-shaped, filamentous cells, were sensitive to the action of static electrical field of high frequency, this pointing to disturbance of cellular membranes structure in these mutants.

摘要

根据对紫外线照射、N-甲基-N'-硝基-N-亚硝基胍、5-溴尿嘧啶、丝裂霉素C、结晶紫的敏感性特征,以及修复噬菌体损伤的能力,将1435-A和1435-24突变体归为uvr-hcr-基因型,17突变体归为uvr-hcr+基因型,35突变体归为lon基因型。紫外线照射后,实验菌株形成了细菌的异形形态,如纺锤形、丝状细胞,对高频静电场的作用敏感,这表明这些突变体的细胞膜结构受到了干扰。

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