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[组织培养条件下精神分裂症患者淋巴细胞与人类胚胎脑细胞相互作用的电子显微镜研究]

[Electron microscopic study of the interaction between lymphocytes of schizophrenic patients and human embryo brain cells under tissue culture conditions].

作者信息

Bonartsev P D, Buravlev V M

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(5):688-92.

PMID:899469
Abstract

The authors convened an electron microscopic study of the interaction of lymphocytes in the peripheral blood of schizophrenic patients with the brain cells of the embryo after a 24-hour joint cell incubation. It was found that in comparison with the lymphocytes of the normals, the lymphocytes of schizophrenic patients much more frequently come into contact with the cells of the brain culture. The lymphocytes of the patients are characterized by an increased amount of cytoplasmatic processes. A maximum amount of lymphocytes which came into contact was seen in experiments on population enriched in activized cells of the lymphocyte in schizophrenic patients. It is particularly the activized lymphocytes of schizophrenic patients that coming into contact called forth degenerative changes in the cells of brain culture in the area of contacts.

摘要

作者进行了一项电子显微镜研究,观察了精神分裂症患者外周血淋巴细胞与胚胎脑细胞在共同培养24小时后的相互作用。结果发现,与正常人的淋巴细胞相比,精神分裂症患者的淋巴细胞与脑培养细胞接触的频率要高得多。患者的淋巴细胞具有细胞质突起数量增加的特点。在对富含精神分裂症患者活化淋巴细胞群体的实验中,观察到接触的淋巴细胞数量最多。尤其是精神分裂症患者的活化淋巴细胞在接触区域会引起脑培养细胞的退行性变化。

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