Sack R B, Rahman M, Yunus M, Khan E H
Division of Community Health, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.
Clin Infect Dis. 1997 Jan;24 Suppl 1:S102-5. doi: 10.1093/clinids/24.supplement_1.s102.
Antimicrobial resistance is becoming increasingly important in the treatment of enteric infections, particularly those due to Shigella, Vibrio cholerae, enterotoxigenic Escherichia coli (associated with traveler's diarrhea), and Salmonella typhi. The rate of antimicrobial resistance is highest in the developing world, where the use of antimicrobial drugs is relatively unrestricted. Of greatest immediate concern is the need for an effective, inexpensive antimicrobial that can be used safely as treatment for small children with dysentery due to Shigella, primarily Shigella dysenteriae type 1.
抗菌素耐药性在肠道感染治疗中日益重要，尤其是由志贺氏菌、霍乱弧菌、产肠毒素大肠杆菌（与旅行者腹泻有关）和伤寒沙门氏菌引起的感染。在发展中世界，抗菌素耐药率最高，那里对抗菌素药物的使用相对不受限制。当前最迫切需要的是一种有效且廉价的抗菌素，它能够安全地用于治疗因志贺氏菌，主要是1型痢疾志贺氏菌引起的小儿痢疾。
