Hancock R E
Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Clin Infect Dis. 1997 Jan;24 Suppl 1:S148-50. doi: 10.1093/clinids/24.supplement_1.s148.
Resistance to antibiotics is becoming a major problem worldwide. Exacerbating this situation is the fact that few new antibiotics are in the development pipeline, and, indeed, no novel class of antibiotics has been introduced into medical practice in more than 20 years. It is proposed that the solutions to the problem of antibiotic resistance will be found only through fundamental research that will probably use biotechnology as a tool. A variety of novel approaches being utilized in university laboratories and biotechnology companies are outlined. Two approaches in particular, namely, Synsorbs and recombinant cationic peptide antimicrobials, that have been developed through the Canadian Bacterial Diseases Network, a national research consortium, are discussed.
抗生素耐药性正成为全球的一个主要问题。使这种情况更加恶化的是，正在研发的新抗生素很少，事实上，20多年来没有新的抗生素类别被引入医学实践。有人提出，只有通过可能将生物技术作为工具的基础研究，才能找到解决抗生素耐药性问题的办法。概述了大学实验室和生物技术公司正在使用的各种新方法。特别讨论了通过加拿大细菌疾病网络（一个国家研究联盟）开发的两种方法，即合成吸附剂和重组阳离子肽抗菌剂。
