细胞周期：与Myc靶向作用
Cell cycle: on target with Myc.
作者信息
Zörnig M, Evan G I
机构信息
Biochemistry of the Cell Nucleus Laboratory, Imperial Cancer Research Fund Laboratories, London, UK.
出版信息
Curr Biol. 1996 Dec 1;6(12):1553-6. doi: 10.1016/s0960-9822(02)70769-0.
PMID:8994810
Abstract
Recent evidence indicates that the c-Myc proto-oncogene activates transcription of cdc25A. The Cdc25A protein phosphatase is required both for progression through mitosis and for Myc-induced apoptosis, making cdc25A the most attractive Myc target gene identified so far.
摘要
最近的证据表明，c-Myc原癌基因可激活cdc25A的转录。细胞周期蛋白依赖性激酶25A（Cdc25A）蛋白磷酸酶对于有丝分裂进程以及Myc诱导的细胞凋亡均是必需的，这使得cdc25A成为迄今为止所鉴定出的最具吸引力的Myc靶基因。
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