Tivol E A, Schweitzer A N, Sharpe A H
Blood Center of Southeastern Wisconsin, Milwaukee 53201-2178, USA.
Curr Opin Immunol. 1996 Dec;8(6):822-30. doi: 10.1016/s0952-7915(96)80011-2.
The past year has seen significant advances in our understanding of the role of the B7-CD28/CTLA-4 pathway in T cell activation and self-tolerance. Recent studies have demonstrated that CTLA-4 is a critical negative regulator of T cell activation and autoreactivity, revealing a previously unsuspected means by which costimulation is involved in the maintenance and breakdown of self-tolerance. Manipulation of this costimulatory pathway in animal models of autoimmunity has shown an important role for this pathway in both the initiation and progression of autoimmune diseases.
在过去一年里，我们对B7-CD28/CTLA-4通路在T细胞活化和自身耐受中的作用的理解取得了重大进展。最近的研究表明，CTLA-4是T细胞活化和自身反应性的关键负调节因子，揭示了共刺激参与自身耐受维持和破坏的一种先前未被怀疑的方式。在自身免疫动物模型中对这条共刺激通路进行操控，已表明该通路在自身免疫疾病的起始和进展中都发挥着重要作用。
