[Clinical aspects of lithium prevention of endogenous phasic-affective psychoses].

The report deals with the results of a long-term (up to 7 years) therapeuticoprophylactic use of lithium salts in 80 patients with manic-depressive psychosis and attack-like schizophrenia. It was possible to confirm the nosological predictiveness of this method in manic-depressive psychosis. The authors show some indications for the use of lithium in periodical schizophrenia with affective and affective-delusional attacks. A study of the pathomorphosis of clinical signs permitted to distinguish 2 types in the dynamics of the disease development during lithium treatment and correlating with different therapeutical effects. The authors analyze the changes of psychopathological structures in the attacks (phases) during lithium salt treatment.