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Genetic mapping of GLCLC, the human gene encoding the catalytic subunit of gamma-glutamyl-cysteine synthetase, to chromosome band 6p12 and characterization of a polymorphic trinucleotide repeat within its 5' untranslated region.

作者信息

Walsh A C, Li W, Rosen D R, Lawrence D A

机构信息

Laboratory of Environmental and Clinical Immunology, Wadsworth Center, New York State Department of Health, Albany 12201-0509, USA.

出版信息

Cytogenet Cell Genet. 1996;75(1):14-6. doi: 10.1159/000134447.

DOI:10.1159/000134447
PMID:8995480
Abstract

The first and rate-limiting step in the formation of glutathione is catalyzed by gamma-glutamylcysteine synthetase (glutamate-cysteine ligase, E.C. 6.3.2.2). Herein, we describe a trinucleotide repeat polymorphism located in the 5' untranslated region of the human gene, GLCLC, that encodes the catalytic subunit of this enzyme, and we genetically map GLCLC to band 6p12, 1.6 cM distal to D6S295.

摘要

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