p53磷酸化：生化及功能后果
p53 Phosphorylation: biochemical and functional consequences.
作者信息
Milczarek G J, Martinez J, Bowden G T
机构信息
Department of Molecular and Cellular Biology, University of Arizona, Life Sciences South, Tucson 85721, USA.
出版信息
Life Sci. 1997;60(1):1-11. doi: 10.1016/s0024-3205(96)00479-1.
PMID:8995526
Abstract
The p53 protein plays a vital role in suppressing the development of cancer. Posttranslational modification through phosphorylation has been postulated to be an important regulatory mechanism of p53 function. Data describing the role of phosphorylation in terms of its effects on several biochemical properties and cellular functions of p53 are examined in the context of how p53 might be "phospho-regulated."
摘要
p53蛋白在抑制癌症发展过程中发挥着至关重要的作用。通过磷酸化进行的翻译后修饰被认为是p53功能的一种重要调节机制。本文从p53可能如何被“磷酸化调节”的角度，审视了关于磷酸化对p53的多种生化特性及细胞功能影响的相关数据。
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