Codd S L, Mallett M J, Halse M R, Strange J H, Vennart W, Van Doorn T
Physics Laboratory, University of Kent, Canterbury, United Kingdom.
J Magn Reson B. 1996 Dec;113(3):214-21. doi: 10.1006/jmrb.1996.0179.
A 3DFT gradient-echo technique has been developed which, in conjunction with series-resonant gradient-coil circuits, can produce three-dimensional NMR images with an echo time of less than 100 microseconds. The method involves a read-gradient waveform composed of two sinusoids of different frequencies. This is an improvement on previous imaging sequences using a single sinusoid where only half of k space was sampled and where the second half was calculated using conjugate symmetry. The inaccuracies involved in the necessary "cut and paste" of k space inevitably lead to artifacts in the final image. The important features of the new method are that with suitable phase encoding all octants of k space are sampled, the RF pulse is applied when the gradients are all zero, and the echo forms when the gradient is essentially constant. This method will allow more extensive application of solid imaging techniques to biological samples in vivo.
一种3DFT梯度回波技术已经被开发出来,该技术与串联谐振梯度线圈电路相结合,可以产生回波时间小于100微秒的三维核磁共振图像。该方法涉及由两个不同频率的正弦波组成的读出梯度波形。这是对先前使用单个正弦波的成像序列的改进,在先前的序列中,只对k空间的一半进行采样,另一半则使用共轭对称性进行计算。k空间必要的“剪切和粘贴”所涉及的不准确性不可避免地会导致最终图像中出现伪影。新方法的重要特点是,通过适当的相位编码对k空间的所有卦限进行采样,当梯度都为零时施加射频脉冲,并且当梯度基本恒定时形成回波。这种方法将允许在体内将固体成像技术更广泛地应用于生物样品。