Maringhini A, Termini A, Patti R, Ciambra M, Biffarella P, Pagliaro L
Divisione di Medicina e Cattedra di Medicina dell'Università, Ospedale V. Cervello, Palermo, Italy.
Am J Gastroenterol. 1997 Jan;92(1):166-7.
Three patients with acute pancreatitis diagnosed while they were taking enalapril are described. In two of these patients, enalapril was the only drug taken immediately before the symptoms began, and other etiologies were accurately excluded. In the third patient, the relationship between enalapril and acute pancreatitis was shown by a rechallenge with the drug that resulted in severe acute pancreatitis. This report is a definite demonstration of the relationship between enalapril and acute pancreatitis. We suggest stopping treatment with enalapril in patients suspected of having acute pancreatitis. We also recommend not rechallenging patients with the drug because of the risk of inducing severe acute pancreatitis.
本文描述了3例在服用依那普利期间被诊断为急性胰腺炎的患者。其中2例患者，依那普利是症状出现前立即服用的唯一药物，且已准确排除其他病因。在第3例患者中，再次使用该药物导致严重急性胰腺炎，从而证实了依那普利与急性胰腺炎之间的关系。本报告明确证实了依那普利与急性胰腺炎之间的关系。我们建议对疑似急性胰腺炎的患者停用依那普利治疗。我们还建议不要对患者再次使用该药物，因为有诱发严重急性胰腺炎的风险。
