原癌基因c-myb在散发性牛淋巴瘤中表达，但在地方流行性牛白血病中不表达。

The proto-oncogene c-myb is expressed in sporadic bovine lymphoma, but not in enzootic bovine leukosis.

作者信息

Asahina M, Ishiguro N, Wu D, Goryo M, Davis W C, Okada K

机构信息

Department of Veterinary Pathology, Faculty of Agriculture, Iwate University, Japan.

出版信息

J Vet Med Sci. 1996 Dec;58(12):1169-74. doi: 10.1292/jvms.58.12_1169.

DOI:10.1292/jvms.58.12_1169

PMID:8996698

Abstract

We examined bovine c-myb gene expression in six samples of sporadic bovine lymphomas (two calf, three thymic and one intermediate) and five of enzootic bovine leukosis. Tumor cells of the sporadic bovine lymphomas were of immature cell lineage (one B lymphoma and five T lymphomas). The c-myb mRNA was expressed in almost all the sporadic bovine lymphomas (except for one thymic form) including a BoCD8 single positive T lymphoma. On the contrary, c-myb was not expressed in mature B lymphomas of enzootic bovine leukosis. The results suggest that c-myb expression is closely associated with tumor cell differentiation of bovine lymphomas.

摘要

我们检测了6份散发性牛淋巴瘤样本（2份犊牛型、3份胸腺型和1份中间型）以及5份地方流行性牛白血病样本中的牛c-myb基因表达情况。散发性牛淋巴瘤的肿瘤细胞属于未成熟细胞谱系（1例B淋巴瘤和5例T淋巴瘤）。c-myb mRNA在几乎所有散发性牛淋巴瘤（1例胸腺型除外）中均有表达，包括1例牛CD8单阳性T淋巴瘤。相反，c-myb在地方流行性牛白血病的成熟B淋巴瘤中不表达。结果表明，c-myb表达与牛淋巴瘤的肿瘤细胞分化密切相关。