Midorikawa Y, Haque Q M
Suzuka University of Medical Science and Technology, Mie, Japan.
Chemotherapy. 1997 Jan-Feb;43(1):31-5. doi: 10.1159/000239532.
Deoxyspergualin (DSG), which was discovered to be an immunosuppressive agent, was examined for its in vivo effect on parasites of rodent malaria. Although the mice that were not treated by DSG had an increased parasite percentage (% parasitemia) until they died, those that were treated with DSG had a decreased parasitemia and finally had 0% parasites. The spleens of infected mice became small by DSG treatment. Parasitemia of mice increased again after DSG treatment was stopped. However, DSG was a polyamine inhibitor. The two other types of polyamine inhibitors used in this study were not effective for decreasing the % parasitemia of Plasmodium berghei. Only DSG was available and the survival time of mice increased. The antiprotozoal effects shown by DSG-even this chemical is an immunosuppressive agent-suggest that there is a relation between the inhibition of the polyamine synthetic pathway or immunosuppression of DSG and the suppressive effect of malarial parasites.
脱氧精胍菌素（DSG）被发现是一种免疫抑制剂，我们检测了它对啮齿类疟原虫的体内作用。未接受DSG治疗的小鼠，其寄生虫百分比（疟原虫血症百分比）不断上升直至死亡，而接受DSG治疗的小鼠疟原虫血症降低，最终寄生虫为0%。经DSG治疗后，受感染小鼠的脾脏变小。停止DSG治疗后，小鼠的疟原虫血症再次上升。然而，DSG是一种多胺抑制剂。本研究中使用的另外两种多胺抑制剂对降低伯氏疟原虫的疟原虫血症百分比无效。只有DSG有效，并且小鼠的存活时间延长。DSG显示出抗原生动物作用——即便这种化学物质是一种免疫抑制剂——这表明多胺合成途径的抑制或DSG的免疫抑制与疟原虫的抑制作用之间存在关联。
