Jin D C, Yoon Y S, Kim Y S, Yoon S A, Ahn S J, Kim S Y, Chang Y S, Bang B K, Koh Y B
Department of Internal Medicine, St. Mary's Hospital, Catholic University of Korea, Seoul, South Korea.
Clin Transplant. 1996 Dec;10(6 Pt 1):471-7.
We analyzed the potential factors that could influence the survival of graft, focused on primary graft living-donor kidney transplantation with cyclosporine (CsA) therapy. 680 cases were enrolled in this study. Patients and graft survival rates were calculated by a Kaplan-Meier product limit estimate with a 1-day time interval. The analyzed variables were donor relationship, HLA matching, recipient age and sex, donor age and sex, ABO blood type compatibility, diabetic status, hepatitis virus infection, donor specific or non-specific blood transfusion and acute rejection episode. The results suggested that acute rejection episode was the most prognostic factor in graft survival. An HLA-matched donor and a young male donor, i.e. a greater donor nephron mass for less recipient body mass, will show better long-term survival. Diabetes and hepatitis B infection have some negative effects on the long-term survival of graft kidney, but age of recipient, donor-specific transfusion and donor-recipient relationship have little effect.
我们分析了可能影响移植物存活的潜在因素，重点关注接受环孢素（CsA）治疗的初次活体供肾移植。本研究共纳入680例患者。采用Kaplan-Meier乘积限估计法，以1天为时间间隔计算患者和移植物存活率。分析的变量包括供受者关系、HLA配型、受者年龄和性别、供者年龄和性别、ABO血型相容性、糖尿病状态、肝炎病毒感染、供者特异性或非特异性输血以及急性排斥反应。结果表明，急性排斥反应是移植物存活的最具预后意义的因素。HLA匹配的供者以及年轻男性供者，即供者肾单位质量与受者体重比值更高时，移植物长期存活率更高。糖尿病和乙型肝炎感染对移植肾的长期存活有一定负面影响，但受者年龄、供者特异性输血以及供受者关系影响较小。
