Fowler C J, Cowburn R F, Joseph J A
Department of Pharmacology, Umeå University, Sweden.
Gerontology. 1997;43(1-2):132-42. doi: 10.1159/000213841.
Recent research into the pathogenesis of Alzheimer's disease (AD) has focused upon the proposed neurotoxic role played by the beta-amyloid peptide. Other important neurochemical disturbances, such as the dramatic breakdown of intracellular signalling, should however not be overlooked. In the present article, the authors attempt to investigate the relationship between signalling disturbances and beta-amyloid and ask the question 'which came first?' The available evidence is discussed, and it is concluded that the need for a wide, rather than restricted, focus on biochemical events associated with AD is required if progress is to be made in the understanding and eventual treatment of this disease.
近期对阿尔茨海默病（AD）发病机制的研究聚焦于β-淀粉样肽所提出的神经毒性作用。然而，其他重要的神经化学紊乱，如细胞内信号传导的显著破坏，不应被忽视。在本文中，作者试图研究信号传导紊乱与β-淀粉样蛋白之间的关系，并提出“哪个先出现？”这一问题。文中讨论了现有证据，并得出结论：如果要在理解和最终治疗这种疾病方面取得进展，就需要广泛而非局限地关注与AD相关的生化事件。
