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[血液生化分析的法医学应用——肌酸磷酸激酶(CPK)和乳酸脱氢酶(LDH)同工酶的研究]

[Forensic application of biochemical blood analysis--studies on CPK and LDH isozymes].

作者信息

Tsuji A, Ogawa T, Fujita H, Ikeda N

机构信息

Department of Legal Medicine, Hirosaki University School of Medicine, Japan.

出版信息

Nihon Hoigaku Zasshi. 1996 Dec;50(6):385-9.

PMID:8997082
Abstract

We analyzed CPK and LDH isozymes of the plasma of cadavers, which give indication of muscle damage in normal blood. The isozyme patterns in cadaveric plasma were different from those in normal plasma. The patterns were classified into five groups in CPK and four groups in LDH, respectively. We could not detect obvious correlation between the cause of death and each classified groups in CPK. In comparison with CPK, we detect the clear relation between the cause of death and isozyme patterns in LDH. All cases of LDH 1 and 5 predominant or LDH 1, 2 and 5 predominant groups had myocardial infarction or other myocardial damage. So LDH isozyme pattern was informative for antemortem cardiac conditions of the cadaver and considered to be useful for conjecturing myocardial damage of the cadaver at least within 24 hours after death.

摘要

我们分析了尸体血浆中的肌酸磷酸激酶(CPK)和乳酸脱氢酶(LDH)同工酶,这些同工酶可指示正常血液中的肌肉损伤情况。尸体血浆中的同工酶模式与正常血浆中的不同。CPK的模式分别分为五组,LDH的模式分为四组。我们未检测到CPK中死亡原因与各分类组之间存在明显相关性。与CPK相比,我们检测到LDH中死亡原因与同工酶模式之间存在明确关系。所有LDH 1和5占主导或LDH 1、2和5占主导的组均患有心肌梗死或其他心肌损伤。因此,LDH同工酶模式可提供有关尸体生前心脏状况的信息,并且被认为至少在死后24小时内对推测尸体的心肌损伤有用。

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