Kawamoto R, Abe M
Department of Internal Medicine, Nomura Municipal Hospital.
Nihon Ronen Igakkai Zasshi. 1996 Nov;33(11):835-9. doi: 10.3143/geriatrics.33.835.
We used ultrasonography to evaluate atherosclerotic lesions in the common carotid arteries of 147 inpatients (82 men, 65 women; mean age, 72.2 years). We sought to determine the relation between these lesions and various risk factors for atherosclerosis, as well as the utility of ultrasonography in quantitative evaluation of atherosclerotic disease. A 7.5 MHz transducer was used and atherosclerotic lesions were evaluated on the basis of the thickness of their intimal-medial complex, which we term wall thickness. The relations between these measurements and age, sex, blood pressure, smoking history, lipid metabolism, diabetes mellitus, and atherosclerotic disease were studied. Wall thickness of the common carotid arteries correlated with age (men: r = 0.45; women: r = 0.38). Brinkman Index (r = 0.25), systolic blood pressure (r = 0.44), diastolic pressure (r = 0.18), and high-density lipoprotein cholesterol (HDL-C, r = -0.23). Multiple regression analysis with these risk factors as explanatory variables showed that age, Brinkman Index, systolic blood pressure, HDL-C, and diabetes mellitus contributed significantly to increased wall thickness. Wall thickness was significantly greater in patients with atherosclerotic disease such as cerebral infarction and ischemic heart diseases. These findings indicate that appropriate treatment for multiple atherosclerotic risk factors may be necessarily in the elderly.
我们使用超声检查来评估147例住院患者（82名男性，65名女性；平均年龄72.2岁）颈总动脉的动脉粥样硬化病变。我们试图确定这些病变与动脉粥样硬化的各种危险因素之间的关系，以及超声检查在动脉粥样硬化疾病定量评估中的效用。使用7.5兆赫的换能器，并根据内膜-中膜复合体的厚度（我们称之为壁厚度）来评估动脉粥样硬化病变。研究了这些测量值与年龄、性别、血压、吸烟史、脂质代谢、糖尿病和动脉粥样硬化疾病之间的关系。颈总动脉的壁厚度与年龄相关（男性：r = 0.45；女性：r = 0.38）、布林克曼指数（r = 0.25）、收缩压（r = 0.44）、舒张压（r = 0.18）以及高密度脂蛋白胆固醇（HDL-C，r = -0.23）。以这些危险因素作为解释变量的多元回归分析表明，年龄、布林克曼指数、收缩压、HDL-C和糖尿病对壁厚度增加有显著影响。在患有脑梗死和缺血性心脏病等动脉粥样硬化疾病的患者中，壁厚度明显更大。这些发现表明，对老年人而言，可能有必要对多种动脉粥样硬化危险因素进行适当治疗。
