轻度实验性肉毒中毒中单纤维肌电图抖动与终板电位的相关性研究。

Correlation between single fibre EMG jitter and endplate potentials studied in mild experimental botulinum poisoning.

作者信息

Lundh H, Schiller H H, Elmqvist D

出版信息

Acta Neurol Scand. 1977 Aug;56(2):141-52. doi: 10.1111/j.1600-0404.1977.tb01418.x.

DOI:10.1111/j.1600-0404.1977.tb01418.x

Abstract

To study the correlation between single fibre EMG jitter and endplate potential amplitude we examined neuromuscular transmission in rats paralysed with botulinum toxin type A with single fibre EMG (SFEMG) in vivo and with intracellular microelectrode techniques in vitro. In muscles that were not completely paralysed SFEMG showed an increased neuromuscular jitter on nerve stimulation and in these muscles endplate potentials were of reduced amplitude. When the nerve stimulation frequency increased the jitter decreased. Intravenous injection of drugs that increase the acetylcholine release and endplate potential amplitude markedly reduced the jitter and the frequency dependence disappeared.

摘要

为研究单纤维肌电图（SFEMG）的肌纤维震颤与终板电位幅度之间的相关性，我们采用体内单纤维肌电图和体外细胞内微电极技术，对注射A型肉毒杆菌毒素致瘫的大鼠的神经肌肉传递进行了研究。在未完全瘫痪的肌肉中，单纤维肌电图显示神经刺激时神经肌肉震颤增加，且这些肌肉的终板电位幅度降低。当神经刺激频率增加时，震颤减小。静脉注射能增加乙酰胆碱释放和终板电位幅度的药物，可显著降低震颤，且频率依赖性消失。