Hagberg B, Hagberg G
Department of Pediatrics, East Hospital, Gothenburg, Sweden.
Acta Paediatr Suppl. 1996 Oct;416:48-52. doi: 10.1111/j.1651-2227.1996.tb14277.x.
Our Swedish population-based cerebral palsy (CP) project started 25 years ago and today covers the birth years 1954-1990, with over 1400 CP cases. This large series (1, 2, 3) has opened new perspectives on time trends and aetiological background factors, where two areas of successively increasing knowledge stand out as particularly helpful. One is the growing amount of biological and clinical data from the continuously increasing cohorts of surviving very preterm infants, the other is the rapidly expanding and refined information from neuroimaging. Bilateral spastic CP (BSCP), including spastic and ataxic diplegia, tetraplegia and spastic-dyskinetic CP, is the most prevalent clinical group of CP syndromes, present in around 75% of preterm and 45% of term CP, and has shown the most significant prevalence changes over time. In this presentation we, therefore, focus on BSCP, also analysed in a collaborative study between southwest Germany and western Sweden and recently presented in a series of four papers (4, 5, 6, 7).
我们基于瑞典人群的脑瘫（CP）项目始于25年前，如今涵盖了1954年至1990年的出生人群，有超过1400例脑瘫病例。这个大型队列（1、2、3）为时间趋势和病因背景因素开启了新的视角，其中两个知识不断增加的领域显得尤为有用。一个是来自存活的极早产儿队列不断增加的生物学和临床数据，另一个是神经影像学迅速扩展和完善的信息。双侧痉挛性脑瘫（BSCP），包括痉挛性和共济失调性双瘫、四肢瘫以及痉挛 - 运动障碍性脑瘫，是脑瘫综合征中最常见的临床类型，约75%的早产脑瘫和45%的足月脑瘫中存在该类型，并且随时间推移其患病率变化最为显著。因此，在本报告中，我们聚焦于双侧痉挛性脑瘫，该研究也在德国西南部和瑞典西部的一项合作研究中进行了分析，最近发表在一系列四篇论文中（4、5、6、7）。
