儿童过敏性紫癜病程中的血清免疫球蛋白水平

Serum immunoglobulin levels in the course of anaphylactoid purpura in children.

作者信息

Similä S, Kouvalainen K, Lanning M

出版信息

Acta Paediatr Scand. 1977 Sep;66(5):537-40. doi: 10.1111/j.1651-2227.1977.tb07943.x.

DOI:10.1111/j.1651-2227.1977.tb07943.x

Abstract

Serum levels of immunoglobulins (IgG, IgA, IgM, IgD and IgE) were determined at frequent intervals in the course of anaphylactoid purpura (AP) in children. AP was cured without complications in 16 out of 26 cases, recurring in 7 cases. Melena was manifested in 9 cases and nephropathy in 5. The levels of IgA and IgM were elevated in AP, but serum IgG, IgD and IgE showed no significant changes. The serum level of IgM was significantly (p less than 0.0125) higher in patients with AP nephropathy than in those with recent AP. The elevated serum IgA and IgM levels are possibly related to the pathogenesis of AP and/or its renal involvement.

摘要

在儿童过敏性紫癜（AP）病程中，定期测定血清免疫球蛋白（IgG、IgA、IgM、IgD和IgE）水平。26例中16例AP治愈无并发症，7例复发。9例出现黑便，5例出现肾病。AP患者IgA和IgM水平升高，但血清IgG、IgD和IgE无显著变化。AP肾病患者血清IgM水平显著（p<0.0125）高于近期患AP者。血清IgA和IgM水平升高可能与AP的发病机制和/或其肾脏受累有关。