Mikhail M G, Smith F A, Gray M, Britton C, Frederiksen S M
Department of Emergency Medicine, St Joseph Mercy Hospital, Ann Arbor, Michigan, USA.
Ann Emerg Med. 1997 Jan;29(1):88-98. doi: 10.1016/s0196-0644(97)70314-7.
To determine whether emergency patients with acute chest pain and low suspicion of acute myocardial infarction (AMI) can be managed cost-effectively and safely in a dedicated chest pain center (CPC) that incorporates mandatory stress testing.
We assembled a prospective observational case series of consecutive adult patients transferred from the emergency department to a nine-bed, 23-hour CPC in a 564-bed community hospital from January 13 through May 31, 1994. In our institution, all emergency patients with acute nontraumatic chest pain of unclear origin, suggestive of myocardial ischemia but with a low probability of AMI, are transferred to the CPC for further evaluation. All patients in whom AMI is ruled out undergo individually appropriate cardiac diagnostic testing in accordance with CPC clinical guidelines. Patients with end-stage coronary artery disease transferred to the CPC for a "rule-out" protocol only did not undergo further diagnostic testing. Admitted and discharged patients were followed through chart review and telephone survey, respectively.
Of the 502 patients transferred to the CPC, 477 (95%) completed follow-up at 14 days. Four hundred ten (86%) were discharged home. Those discharged after diagnostic evaluation yielded negative findings had 100% survival and zero diagnosis of AMI at 5-month follow-up. Overall mortality and incidence of AMI on long-term follow-up for all patients transferred to the CPC were .4% and .2%, respectively. Sixty-seven patients (13%) were admitted from the CPC, of whom 44 (66%) had a final diagnosis of ischemic heart disease (IHD) or AMI. Twenty-four patients with IHD (55%; 6% of stress-tested group) were identified only on further stress testing. Of these patients, seven underwent percutaneous transluminal coronary angioplasty or coronary artery bypass grafting during hospitalization. All were discharged home without major morbidity. Four hundred twenty-four patients (84%) underwent stress testing. The cost of mandatory stress testing to identify one patient with IHD after AMI was ruled out was $3,125. An average cost-per-case savings of 62% was achieved for each patient transferred to the CPC who would have been hospitalized before the inception of the CPC.
Mandatory stress testing is a safe, cost-effective, and valuable diagnostic and prognostic tool in CPC patients.
确定对于急性胸痛且急性心肌梗死(AMI)可能性低的急诊患者,在设有强制性负荷试验的专门胸痛中心(CPC)进行管理是否具有成本效益且安全。
我们收集了1994年1月13日至5月31日期间从急诊科转至一家拥有564张床位的社区医院中一个设有9张床位、23小时开放的胸痛中心的成年患者的前瞻性观察病例系列。在我们机构,所有病因不明的急性非创伤性胸痛急诊患者,疑似心肌缺血但AMI可能性低,均被转至胸痛中心进行进一步评估。所有排除AMI的患者均按照胸痛中心临床指南进行个体化适当的心脏诊断检查。仅因“排除”方案转至胸痛中心的终末期冠状动脉疾病患者未接受进一步诊断检查。分别通过病历审查和电话调查对入院和出院患者进行随访。
转至胸痛中心的502例患者中,477例(95%)在14天时完成随访。410例(86%)出院回家。经诊断评估结果为阴性而出院的患者在5个月随访时生存率为100%,且无AMI诊断。转至胸痛中心的所有患者长期随访的总体死亡率和AMI发生率分别为0.4%和0.2%。67例(13%)患者从胸痛中心入院,其中44例(66%)最终诊断为缺血性心脏病(IHD)或AMI。仅在进一步负荷试验中发现24例IHD患者(55%;占负荷试验组的6%)。这些患者中有7例在住院期间接受了经皮腔内冠状动脉成形术或冠状动脉旁路移植术。所有患者均出院回家,无严重并发症。424例(84%)患者接受了负荷试验。排除AMI后识别1例IHD患者的强制性负荷试验成本为3125美元。对于在胸痛中心设立之前本应住院的转至胸痛中心的每位患者,平均每例节省成本62%。
强制性负荷试验对于胸痛中心患者是一种安全、具有成本效益且有价值的诊断和预后工具。